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579002 Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem

Tamoxifen, 4-Hydroxy-, (Z), CAS 68047-06-3, is a cell-permeable, active metabolite of Tamoxifen that is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II

Primary Target: PKC
579002
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
68047-06-3C₂₆H₂₉NO₂
Description
OverviewA cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).
Catalogue Number579002
Brand Family Calbiochem®
Synonyms(Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II
References
ReferencesGundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.
Product Information
CAS number68047-06-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₂₉NO₂
Chemical formulaC₂₆H₂₉NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationTamoxifen, 4-Hydroxy-, (Z), CAS 68047-06-3, is a cell-permeable, active metabolite of Tamoxifen that is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
Biological Information
Primary TargetPKC
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSL1210000
Safety Information
R PhraseR: 22-45-60-61-64

Harmful if swallowed.
May cause cancer.
May impair fertility.
May cause harm to the unborn child.
May cause harm to breastfed babies.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
579002 0

Documentation

Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem Certificates of Analysis

TitleLot Number
579002

References

Reference overview
Gundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-February-2012 RFH
Synonyms(Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II
DescriptionA cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
FormWhite solid
CAS number68047-06-3
RTECSSL1210000
Chemical formulaC₂₆H₂₉NO₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityEthanol (20 mg/ml, heating may be required) or Methanol (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesGundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.