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654257 TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem

The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline

654257
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
303997-35-5C₁₆H₈ClF₃N₄S

Products

Catalogue NumberPackaging Qty/Pack
654257-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
Catalogue Number654257
Brand Family Calbiochem®
Synonyms8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
References
ReferencesGururaja, T.L., et al. 2007. Chem. Biol. 14, 1105.
Product Information
CAS number303997-35-5
FormLight yellow powder
Hill FormulaC₁₆H₈ClF₃N₄S
Chemical formulaC₁₆H₈ClF₃N₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
654257-10MG 04055977184648

Documentation

TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem Certificates of Analysis

TitleLot Number
654257

References

Reference overview
Gururaja, T.L., et al. 2007. Chem. Biol. 14, 1105.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
DescriptionA cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
FormLight yellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number303997-35-5
Chemical formulaC₁₆H₈ClF₃N₄S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGururaja, T.L., et al. 2007. Chem. Biol. 14, 1105.