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613225 TJU103

A non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding.

TJU103 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-Indolylmethylene)-isonicotinic Hydrazone

Primary Target: Blocks stable CD4-MHC class II binding
613225
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
10245-44-0C₁₅H₁₂N₄O
Description
Overview

This product has been discontinued.





A non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, suggesting its potential as a novel immunosuppressant. Does not exhibit any toxic effects in vivo, with normal lymphocyte cellularity and subset composition in the spleen and lymph nodes of mice 24 h after injection.
Catalogue Number613225
Brand Family Calbiochem®
SynonymsN-(3-Indolylmethylene)-isonicotinic Hydrazone
References
ReferencesLi, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73.
Product Information
CAS number10245-44-0
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₅H₁₂N₄O
Chemical formulaC₁₅H₁₂N₄O
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetBlocks stable CD4-MHC class II binding
Purity≥98% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
613225 0

Documentation

TJU103 Certificates of Analysis

TitleLot Number
613225

References

Reference overview
Li, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsN-(3-Indolylmethylene)-isonicotinic Hydrazone
DescriptionA non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, suggesting its potential as a novel immunosuppressant. Does not exhibit any toxic effects in vivo, with normal lymphocyte cellularity and subset composition in the spleen and lymph nodes of mice 24 h after injection.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number10245-44-0
Chemical formulaC₁₅H₁₂N₄O
Structure formulaStructure formula
Purity≥98% by HPLC (sum of two isomers)
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesLi, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73.