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14-912 TGFBR-1 Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in Kinase Assays.

TGFBR-1 Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-912
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-912M when ordering the 250 µg size.
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-912
Brand Family Upstate
Trade Name
  • Upstate
DescriptionTGFBR-1 Protein, active, 10 µg
OverviewN-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.
Alternate Names
  • TGF-beta receptor type-1
  • TGFR-1
  • Transforming growth factor-beta receptor type I
  • TGF-beta receptor type I
  • TbetaR-I
  • TGF-beta type I receptor
  • Serine/threonine-protein kinase receptor R4
  • SKR4
  • Activin receptor-like kinase 5
  • ALK-5
Background InformationTransforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS).
References
Product Information
Presentation50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Quality LevelMQ100
Applications
ApplicationActive, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • TGFBR1
Protein TargetTGFBR1
Purification MethodGlutathione agarose affinity chromatography
Target Sub-FamilyTKL
UniProt Number
Molecular Weight62 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by phosphorylation of casein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
Packaging Information
Material Size10 µg
Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-912M when ordering the 250 µg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-912 04053252375163

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-912M TGFBR-1 Protein, active, 250 µg

Product Families

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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases