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GF313 TGF- α Protein, Human Recombinant Animal Free

Transforming growth factor alpha (TGF-α) is an EGF-related polypeptide growth factor that signals through the EGF receptor & stimulates the proliferation of a wide range of epidermal & epithel

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01135 Entrez Gene Number: NM_001099691.1, NM_003236.2
GF313
100 µg  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

SourcePurity
E. coli Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue NumberGF313
DescriptionTGF- α Protein, Human Recombinant Animal Free
Alternate Names
  • Transforming growth factor alpha
  • TGFa
  • TGF alpha
  • EGF-like TGF
  • TGF type 1
Background InformationTransforming growth factor alpha (TGF-α) is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
Product Information
Formulation
PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
ApplicationTransforming growth factor alpha (TGF-α) is an EGF-related polypeptide growth factor that signals through the EGF receptor & stimulates the proliferation of a wide range of epidermal & epithelial cells. Manufactured using all non-animal reagents.
Biological Information
PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
SourceE. coli
Cross ReactivityChicken, Mouse, Rat
Entrez Gene Number
UniProt Number
Product Usage Statements
Quality AssuranceBioactivity assay: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
Packaging Information
Material Size100 µg
Global Trade Item Number
Catalogue Number GTIN
GF313 04053252691492