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567735 Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem

567735
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Overview

Key Spec Table

CAS #Empirical Formula
1670-26-4C₂₃H₄₉N₂O₅P

Products

Catalogue NumberPackaging Qty/Pack
567735-10MG Plastic ampoule 10 mg
Description
OverviewSPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
Catalogue Number567735
Brand Family Calbiochem®
SynonymsSPC, lyso-Sphingomyelin
References
ReferencesBerger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res. 669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
Product Information
CAS number1670-26-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₄₉N₂O₅P
Chemical formulaC₂₃H₄₉N₂O₅P
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetA potent mitogen
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
567735-10MG 04055977190908