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567735
Sigma-AldrichSphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.
More>>SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
Catalogue Number
567735
Brand Family
Calbiochem®
Synonyms
SPC, lyso-Sphingomyelin
References
References
Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885. Dettbarn, C., et al. 1995. Brain Res.669, 79. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem Certificates of Analysis
Title
Lot Number
567735
References
Reference overview
Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885. Dettbarn, C., et al. 1995. Brain Res.669, 79. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-September-2008 RFH
Synonyms
SPC, lyso-Sphingomyelin
Description
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss 3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
Form
White solid
CAS number
1670-26-4
Chemical formula
C₂₃H₄₉N₂O₅P
Structure formula
Purity
≥98% by TLC
Solubility
Chloroform:Methanol (2:1) (1 mg/ml)
Storage
Protect from moisture -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity
Standard Handling
References
Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885. Dettbarn, C., et al. 1995. Brain Res.669, 79. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.