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539572 Serine/Threonine Kinase Inhibitor Set - Calbiochem

The Serine/Threonine Kinase Inhibitor Set controls the biological activity of Serine/Threonine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PKA
539572
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
539572-1SET Glass bottle 1 set
Description
OverviewA convenient set that offers several highly selective serine/threonine kinase inhibitors. Set contains 250 µg of protein kinase C inhibitor, Bisindolylmaleimide I (Cat. No. 203290); 1 mg of protein kinase A inhibitor, H-89, Dihydrochloride (Cat. No. 371963); 1 mg of PKG inhibitor, Protein Kinase G Inhibitor (Cat. No. 370654); 1 mg of MLCK inhibitor, ML-7 (Cat. No. 475880); 1 mg of CaM kinase II inhibitor, KN-93 (Cat. No. 422708); and 100 µg of the broad range Serine/Threonine Kinase inhibitor, Staurosporine (Cat. No. 569397). Supplied with a data sheet.
Catalogue Number539572
Brand Family Calbiochem®
Application Data
References
ReferencesMartiny, G., et al. 1993. J. Biol. Chem. 268, 9194.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
Simu, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Saitoh, M., et al. J. Biol. Chem. 262, 7796.
Glass, D.B., et al. 1983. Biochem. J. 213, 159.
Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207.
Meyer, T., et al. 1989. Int. J. Cancer 43, 851.
Product Information
FormSolid
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKA
Secondary targetPKC, MLCK, Cam kinase II, PKG
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/25-36/37/38-45-63

Toxic by inhalation and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
Possible risk of harm to the unborn child.
S PhraseS: 22-36/37/39-45-53

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions of each inhibitor are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539572-1SET 04055977194715

Documentation

Serine/Threonine Kinase Inhibitor Set - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Serine/Threonine Kinase Inhibitor Set - Calbiochem Certificates of Analysis

TitleLot Number
539572

References

Reference overview
Martiny, G., et al. 1993. J. Biol. Chem. 268, 9194.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
Simu, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Saitoh, M., et al. J. Biol. Chem. 262, 7796.
Glass, D.B., et al. 1983. Biochem. J. 213, 159.
Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207.
Meyer, T., et al. 1989. Int. J. Cancer 43, 851.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-September-2007 JSW
Application Data
DescriptionA convenient set that offers several highly selective serine/threonine kinase inhibitors. Kinases play an important role in numerous signaling cascades. Highly selective protein kinase inhibitors are useful for dissecting these cascades to determine which specific kinases are involved in producing particular biological effects. The Serine/Threonine Kinase Inhibitor Set contains the following highly selective serine/ threonine kinase inhibitors in one convenient set:

• Bisindolylmaleimide I (Cat. No. 203290), 250 µg
• H-89, Dihydrochloride (Cat. No. 371963), 1 mg
• KN-93 (Cat. No. 422708), 1 mg
• ML-7 (Cat. No. 475880), 1 mg
• Protein Kinase G Inhibitor (Cat. No. 370654), 1 mg
• Staurosporine (Cat. No. 569397), 100 µg
FormSolid
SolubilityH₂O (1 mg/ml; Protein Kinase G Inhibitor)
DMSO (1 mg/ml; all other inhibitors)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions of each inhibitor are stable for up to 3 months at -20°C.
Toxicity Multiple Toxicity Values, refer to MSDS
ReferencesMartiny, G., et al. 1993. J. Biol. Chem. 268, 9194.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
Simu, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Saitoh, M., et al. J. Biol. Chem. 262, 7796.
Glass, D.B., et al. 1983. Biochem. J. 213, 159.
Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207.
Meyer, T., et al. 1989. Int. J. Cancer 43, 851.