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563080 Salinomycin

Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.

Salinomycin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
563080
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53003-10-4C₄₂H₇₀O₁₁
Description
OverviewSalinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
Catalogue Number563080
Brand Family Calbiochem®
References
ReferencesGupta, P.B., et al. 2009. Cell. 138, 1.
Product Information
CAS number53003-10-4
FormWhite to white with yellow cast
Hill FormulaC₄₂H₇₀O₁₁
Chemical formulaC₄₂H₇₀O₁₁
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 25

Toxic if swallowed.
S PhraseS: 45

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
563080 0

Documentation

Salinomycin SDS

Title

Safety Data Sheet (SDS) 

Salinomycin Certificates of Analysis

TitleLot Number
563080

References

Reference overview
Gupta, P.B., et al. 2009. Cell. 138, 1.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-November-2019 JSW
DescriptionSalinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
FormWhite to white with yellow cast
CAS number53003-10-4
Chemical formulaC₄₂H₇₀O₁₁
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityMethanol (10 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
Merck USA index13, 8415
ReferencesGupta, P.B., et al. 2009. Cell. 138, 1.