509105 Sigma-AldrichSTAT3/STAT5 Dual Inhibitor, SH-4-54 - CAS 1456632-40-8 - Calbiochem
A cell-permeable BP-1-102 analog that targets STAT3 and STAT5 with comparable affinity.
More>> A cell-permeable BP-1-102 analog that targets STAT3 and STAT5 with comparable affinity. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: SH-04-54, SH0454, SH454, STAT3 Inhibitor XIX, STAT5 Inhibitor IV, 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)benzoic acid
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1456632-40-8 | C₂₉H₂₇F₅N₂O₅S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 5.09105.0001 | Glass bottle | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable BP-1-102 (Cat. no. 573132) analog that targets STAT3 and STAT5 with comparable affinity and is 4-fold more potent in competing against phosphopeptide for binding SH2 domain of STAT3 over STAT1, exhibiting little potency against upstream kinases or the activation of 21 GPCRs, and displaying much reduced or no affinity toward other kinases in a 101-panel screen. Selectively inhibits cellular STAT3 Y705, but not S727, phosphorylation (0.5 to 5 µM) and is a more potent anticancer agent than BP-1-102 against gliobalstoma (GMB) patients-derived brain tumor stem cell (BTSC) in cultures (IC50 from 42 to 530 nM). Reported to penetrate blood-brain-barrier in mice and effectively inhibit BT73 glioma proliferation in xenografted murine brain (10 mg/kg/d via i.p.; 4 d on/ 3 d off) in vivo. |
| Catalogue Number | 509105 |
| Brand Family | Calbiochem® |
| Synonyms | SH-04-54, SH0454, SH454, STAT3 Inhibitor XIX, STAT5 Inhibitor IV, 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)benzoic acid |
| References | |
|---|---|
| References | Haftchenary, S., et al. 2013. ACS Med. Chem. Lett. 4, In press. |
| Product Information | |
|---|---|
| CAS number | 1456632-40-8 |
| Form | White powder |
| Hill Formula | C₂₉H₂₇F₅N₂O₅S |
| Chemical formula | C₂₉H₂₇F₅N₂O₅S |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | STAT3 |
| Secondary target | STAT5 |
| Purity | ≥94% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.09105.0001 | 04055977261486 |