Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

509707 (S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine

Primary Target: GluK1
509707
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
140187-25-3C₇H₈IN₃O₄
Description
Overview

This product has been discontinued.



A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number509707
Brand Family Calbiochem®
Synonyms(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
References
ReferencesBhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.
Product Information
CAS number140187-25-3
FormWhite solid
Hill FormulaC₇H₈IN₃O₄
Chemical formulaC₇H₈IN₃O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGluK1
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
509707 0

Documentation

(S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-February-2014 JSW
Synonyms(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
DescriptionA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number140187-25-3
Chemical formulaC₇H₈IN₃O₄
Structure formulaStructure formula
Purity≥98% by HPLC
Solubility1N NaOH (25 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.