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557440 Ru360 - Calbiochem

Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).

Ru360 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃

Primary Target: Ca2+ uptake into mitochondria in vitro
557440
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂H₂₆Cl₃N₈O₅Ru₂

Products

Catalogue NumberPackaging Qty/Pack
557440-1SET Glass bottle 1 set
557440-500UG Plastic ampoule 500 μg
Description
OverviewA cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels.
Note: 1 set = 10 x 100 µg.
Catalogue Number557440
Brand Family Calbiochem®
Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
References
ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
Product Information
ATP CompetitiveN
FormGreen solid
Hill FormulaC₂H₂₆Cl₃N₈O₅Ru₂
Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCa2+ uptake into mitochondria in vitro
Primary Target IC<sub>50</sub>184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
Purity≥97%
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557440-1SET 07790788051501
557440-500UG 04055977268089

Documentation

Ru360 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ru360 - Calbiochem Certificates of Analysis

TitleLot Number
557440

References

Reference overview
Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-August-2021 JSW
Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
DescriptionA cell-permeable oxygen bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 0.34 nM) and specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (for complete block after incubation with ~10 µM of Ru360 for 30 min. Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction even at micromolar levels.
FormGreen solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
Structure formulaStructure formula
Purity≥97%
SolubilityDeoxygenated H₂O (0.5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
Ying, W.-L., et al. 1991. Biochemistry 30, 4949.