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555580 Ribavirin - CAS 36791-04-5 - Calbiochem

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5'-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

Ribavirin - CAS 36791-04-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole

555580
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
36791-04-5C₈H₁₂N₄O₅
Description
OverviewA non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.
Catalogue Number555580
Brand Family Calbiochem®
Synonyms1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole
References
ReferencesLi, W., et al. 1999. Oncol. Res. 11, 243.
Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653.
Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
Kakumu, S., et al. 1993. Gastroenterology 105, 507.
Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123.
Product Information
CAS number36791-04-5
FormWhite solid
Hill FormulaC₈H₁₂N₄O₅
Chemical formulaC₈H₁₂N₄O₅
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC, ≥99% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXZ4250000
Safety Information
R PhraseR: 61

May cause harm to the unborn child.
S PhraseS: 3/7/9-22-45-53

Keep container tightly closed, in a cool well ventilated place.
Do not breathe dust.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
555580 0

Documentation

Ribavirin - CAS 36791-04-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ribavirin - CAS 36791-04-5 - Calbiochem Certificates of Analysis

TitleLot Number
555580

References

Reference overview
Li, W., et al. 1999. Oncol. Res. 11, 243.
Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653.
Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
Kakumu, S., et al. 1993. Gastroenterology 105, 507.
Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-May-2008 RFH
Synonyms1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole
DescriptionA non-interferon-inducing, broad spectrum antiviral nucleoside that is active against RSV, HIV, HCV and other infectious agents. Inhibits the growth of human myeloma 8226 cells (IC50 = 40 µM) and ovarian carcinoma OVCAR-5 cells (IC50 = 35 µM). Its metabolite, ribavirin-5'-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. Antiviral effects of Ribavirin can be reversed by depriving infected cells of methionine or isoleucine.
FormWhite solid
CAS number36791-04-5
RTECSXZ4250000
Chemical formulaC₈H₁₂N₄O₅
Structure formulaStructure formula
Purity≥99% by HPLC, ≥99% by TLC
SolubilityDMSO and H₂O (20 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 8198
ReferencesLi, W., et al. 1999. Oncol. Res. 11, 243.
Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653.
Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
Kakumu, S., et al. 1993. Gastroenterology 105, 507.
Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123.