504043 Sigma-AldrichRho Inhibitor II, Y16 - CAS 429653-73-6 - Calbiochem
Synonyms: LARG Rho-Binding Domain Blocker, (E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione, (4E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenyl-3,5-pyrazolidinedione, p115 Rho-Binding Domain Blocker, PDZ Rho-Binding Domain Blocker
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Overview
Key Spec Table
CAS # | Empirical Formula |
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429653-73-6 | C₂₄H₂₀N₂O₃ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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5.04043.0001 | Glass bottle | 10 mg |
Description | |
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Overview | A cell-permeable pyrazolidinedione compound that is shown to target RhoGEF DH-PH domain junction with high affinity (Kd = 65 nM) and effetively prevent RhoGEFs LARG, p115, and PDZ from interacting with RhoA, while displaying little potency against DBL-RhoA, LBC-RhoA, intersectin-Cdc42, or TrioN-Cdc42 interaction. Shown to completely prevent serum-induced activation of cellular RhoA, but not Cdc42 or Rac1, in NIH-3T3 cultures (10 µM) and RhoA downstream signaling events. Greatly synergizes with Rho GEF-binding domain blocker Rhosin (Cat. No. 555460) in blocking RhoA-LARG interaction and in preventing cellular RhoA activation (both drug at 5 µM). |
Catalogue Number | 504043 |
Brand Family | Calbiochem® |
Synonyms | LARG Rho-Binding Domain Blocker, (E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione, (4E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenyl-3,5-pyrazolidinedione, p115 Rho-Binding Domain Blocker, PDZ Rho-Binding Domain Blocker |
References | |
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References | Shang, X., et al. 2013. Proc. Natl. Acad. Sci. USA. 110, 3155. |
Product Information | |
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CAS number | 429653-73-6 |
Form | Orange powder |
Hill Formula | C₂₄H₂₀N₂O₃ |
Chemical formula | C₂₄H₂₀N₂O₃ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | RhoGEF |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
5.04043.0001 | 04055977264258 |