500496 Sigma-AldrichPorcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
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Primary Target:
Porcupine (Porcn)-mediated Wnt palmitoylation
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1243243-89-1 | C₂₅H₂₁N₃O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 5.00496.0001 | Glass bottle | 10 mg | |
| 5.00496.0002 | Glass bottle |
| Description | |
|---|---|
| Overview | A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat. No. 681671) in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5 mg/kg & 10 mg/kg p.o.) in vivo. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500496 |
| Brand Family | Calbiochem® |
| Synonyms | Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide |
| References | |
|---|---|
| References | Proffitt, K.D., et al. 2013. Cancer Res. 73, 502. |
| Product Information | |
|---|---|
| CAS number | 1243243-89-1 |
| Form | Off-white powder |
| Hill Formula | C₂₅H₂₁N₃O |
| Chemical formula | C₂₅H₂₁N₃O |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Porcupine (Porcn)-mediated Wnt palmitoylation |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.00496.0001 | 04055977245615 |
| 5.00496.0002 | 04054839067495 |