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525325 Phosphotyrosine Phosphatase Inhibitor Set (Vanadium)

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Na+,K+-ATPase
525325
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.





Contains 5 g of Sodium Orthovanadate (Cat. No. 567540), 10 mg each of bpV(phen) (Cat. No. 203695), and mpV(pic) (Cat. No. 475950).
Catalogue Number525325
Brand Family Calbiochem®
References
Product Information
FormSolid
Applications
Biological Information
Primary TargetNa+,K+-ATPase
Secondary targetATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
525325 0

Documentation

Phosphotyrosine Phosphatase Inhibitor Set (Vanadium) Certificates of Analysis

TitleLot Number
525325
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-June-2008 JSW
DescriptionProtein Tyrosine Phosphatases (PTPs) and Protein Tyrosine Kinases (PTKs) are gene families encoding important proteins involved in signal transduction. PTPs can be classified as either tyrosine-specific or dual-specific based on their phosphatase activity. Diversity of PTP family includes both receptor -like transmembrane proteins and soluble cytosolic proteins. Each PTP contains a highly conserved catalytic domain of ~240 residues that share high sequence similarity throughout the family. The structures of PTP catalytic domains are highly conserved. Hence, the structural and functional diversity within the family depend on structures of noncatalytic regulatory and targeting domains attached to the N- and C- terminals of the catalytic domain. The catalytic site of PTP resides within a crevice on the molecule's surface. The base of the catalytic site is formed by the residues His214 through Arg221.

PTP inhibitors serve as valuable tools in studying the functions of these enzymes as also serve as potential therapeutic agents. To assess the physiological function of PTPases, specific and selective inhibitors of peptidic and nonpeptidic nature have been developed.

The Calbiochem® brand has assembled a set containing 3 inhibitors, which target phosphotyrosine phosphatase with different specificity, for your research needs.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Toxicity Multiple Toxicity Values, refer to MSDS