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524390 Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

Strong irritant for mouse skin, but only moderately active as a tumor promoter.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDBu, PKC Activator II

Primary Target: Na+,K+- ATPase
524390
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
37558-16-0C₂₈H₄₀O₈

Products

Catalogue NumberPackaging Qty/Pack
524390-1MG Alu drum 1 mg
524390-5MG Alu drum 5 mg
Description
OverviewStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.
Catalogue Number524390
Brand Family Calbiochem®
SynonymsPDBu, PKC Activator II
References
ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
Lee, E.J., et al. 1994. Brain Res. 665, 127.
Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
Product Information
CAS number37558-16-0
ATP CompetitiveN
FormWhite to light yellow solid
Hill FormulaC₂₈H₄₀O₈
Chemical formulaC₂₈H₄₀O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNa+,K+- ATPase
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEK7767000
Safety Information
R PhraseR: 26/27/28-36/37/38-40-41

Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
Risk of serious damage to eyes.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
524390-1MG 04055977271546
524390-5MG 04055977271553

Documentation

Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem Certificates of Analysis

TitleLot Number
524390

References

Reference overview
Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
Lee, E.J., et al. 1994. Brain Res. 665, 127.
Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-December-2024 JSW
SynonymsPDBu, PKC Activator II
DescriptionStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
FormWhite to light yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number37558-16-0
RTECSEK7767000
Chemical formulaC₂₈H₄₀O₈
Structure formulaStructure formula
Purity≥99% by HPLC
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
Lee, E.J., et al. 1994. Brain Res. 665, 127.
Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.