Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

516854 Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
516854
  
Purchase on Sigma-Aldrich

Overview

Description
Overview

This product has been discontinued.



Enzymatic component of the holotoxin. Has both NAD-glycohydrolase and ADP-ribosyltransferase activities. Inhibits neutrophil-mediated inflammation in vivo via its ADP-ribosylation activity. Unable to penetrate cells in the absence of the B oligomer.
Catalogue Number516854
Brand Family Calbiochem®
References
ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
Tamura, M., et al. 1982. Biochemistry 21, 5516.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
ReversibleN
Biological Information
Primary TargetHas both NAD-glycohydrolase and ADP-ribosyltransferase activities
PuritySingle major band by SDS-PAGE
Physicochemical Information
Cell permeableN
Contaminants≤0.1% holotoxin by CHO cell assay
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
Global Trade Item Number
Catalogue Number GTIN
516854 0