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516090 Penciclovir - CAS 39809-25-1 - Calbiochem

A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.

Penciclovir - CAS 39809-25-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one

516090
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
39809-25-1C₁₀H₁₅N₅O₃
Description
OverviewA carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
Catalogue Number516090
Brand Family Calbiochem®
Synonyms2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
References
ReferencesLeary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
Thust, R., et al. 1996. Antiviral Res. 31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
Harnden, M.R. 1989. J. Med. Chem. 32, 1738.
Product Information
CAS number39809-25-1
FormWhite solid
Hill FormulaC₁₀H₁₅N₅O₃
Chemical formulaC₁₀H₁₅N₅O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 46-60-61

May cause heritable genetic damage.
May impair fertility.
May cause harm to the unborn child.
S PhraseS: 36/37/39-45-53

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
516090 0

Documentation

Penciclovir - CAS 39809-25-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Penciclovir - CAS 39809-25-1 - Calbiochem Certificates of Analysis

TitleLot Number
516090

References

Reference overview
Leary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
Thust, R., et al. 1996. Antiviral Res. 31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
Harnden, M.R. 1989. J. Med. Chem. 32, 1738.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-May-2008 RFH
Synonyms2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
DescriptionA synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number39809-25-1
Chemical formulaC₁₀H₁₅N₅O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityAqueous buffer, pH 2.0 (10 mg/ml) or H₂O (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index15, 7083
ReferencesLeary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
Thust, R., et al. 1996. Antiviral Res. 31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
Harnden, M.R. 1989. J. Med. Chem. 32, 1738.