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580555 Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

Antitumor and antileukemic agent isolated from the bark of the yew tree.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®

Primary Target: Promotes assembly of microtubules and inhibits tubulins disassembly
580555
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

Products

Catalogue NumberPackaging Qty/Pack
580555-100MG Plastic ampoule 100 mg
580555-25MG Plastic ampoule 25 mg
580555-5MG Glass bottle 5 mg
Description
OverviewAntitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
Catalogue Number580555
Brand Family Calbiochem®
SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
References
ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
Product Information
CAS number33069-62-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₄₇H₅₁NO₁₄
Chemical formulaC₄₇H₅₁NO₁₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPromotes assembly of microtubules and inhibits tubulins disassembly
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDA8340700
Safety Information
R PhraseR: 37/38-41-46-60

Irritating to respiratory system and skin.
Risk of serious damage to eyes.
May cause heritable genetic damage.
May impair fertility.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
580555-100MG 04055977265507
580555-25MG 04055977265514
580555-5MG 04055977265521

Documentation

Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem Certificates of Analysis

TitleLot Number
580555

References

Reference overview
Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
FormWhite solid
CAS number33069-62-4
RTECSDA8340700
Chemical formulaC₄₇H₅₁NO₁₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 6982
ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.