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540211 PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem

The PTP Inhibitor IV, also referenced under CAS 329317-98-8, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV

Primary Target: SHP-2
540211
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
329317-98-8C₂₆H₂₆F₆N₂O₄S₂

Products

Catalogue NumberPackaging Qty/Pack
540211-10MG Plastic ampoule 10 mg
Description
OverviewAn uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP; IC50 = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-ς, PTP-β, and PTP-µ, respectively).
Catalogue Number540211
Brand Family Calbiochem®
Synonymsbis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV
References
ReferencesHuang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835.
Product Information
CAS number329317-98-8
ATP CompetitiveY
FormWhite to off-white solid
Hill FormulaC₂₆H₂₆F₆N₂O₄S₂
Chemical formulaC₂₆H₂₆F₆N₂O₄S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSHP-2
Primary Target IC<sub>50</sub>1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
540211-10MG 04055977268676

Documentation

PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem Certificates of Analysis

TitleLot Number
540211

References

Reference overview
Huang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835.

Citations

Title
  • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision18-April-2011 RFH
    Synonymsbis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV
    DescriptionAn uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC50 = 1.8 µM), PTP1B (IC50 = 2.5 µM), PTP-ε (IC50 = 8.4 µM), PTP-Meg-2 (IC50 = 13 µM), PTP-ς (IC50 = 20 µM), PTP-β (IC50 = 6.4 µM), and PTP-µ (IC50 = 6.7 µM).
    FormWhite to off-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number329317-98-8
    Chemical formulaC₂₆H₂₆F₆N₂O₄S₂
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (10 mg/ml) or ACN
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesHuang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835.
    Citation
  • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
    		•