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529578 PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I

529578
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1087-07-6C₁₅H₁₂OS₂
Description
Overview

This product has been discontinued.



A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
Catalogue Number529578
Brand Family Calbiochem®
Synonyms2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I
References
ReferencesRayter, S., et al. 2008. Oncogene 27, 1036.
Product Information
CAS number1087-07-6
FormYellow solid
Hill FormulaC₁₅H₁₂OS₂
Chemical formulaC₁₅H₁₂OS₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
529578 0

Documentation

PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem Certificates of Analysis

TitleLot Number
529578

References

Reference overview
Rayter, S., et al. 2008. Oncogene 27, 1036.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I
DescriptionA cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1087-07-6
Chemical formulaC₁₅H₁₂OS₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (1.5 mg/ml); Do Not Warm
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesRayter, S., et al. 2008. Oncogene 27, 1036.