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550602 PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem

550602
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Overview

Key Spec Table

CAS #Empirical Formula
1186654-00-1C₁₈H₁₈F₂N₂O₆S₂

Products

Catalogue NumberPackaging Qty/Pack
550602-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
Catalogue Number550602
Brand Family Calbiochem®
SynonymsPyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
References
ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
Product Information
CAS number1186654-00-1
FormWhite powder
Hill FormulaC₁₈H₁₈F₂N₂O₆S₂
Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
550602-10MG 04055977268874