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539684 PKA Inhibitor 6-22 Amide - CAS 121932-06-7 - Calbiochem

The PKA Inhibitor 6-22 Amide, also referenced under CAS 121932-06-7, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, Protein Kinase A Inhibitor 6-22 Amide, PKA Inhibitor VIII

Primary Target: PKA
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
121932-06-7C₈₀H₁₃₀N₂₈O₂₄
Description
OverviewA potent and competitive inhibitor of protein kinase A (Ki = 1.7 nM).
Catalogue Number539684
Brand Family Calbiochem®
SynonymsPKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, Protein Kinase A Inhibitor 6-22 Amide, PKA Inhibitor VIII
References
ReferencesGlass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
Kemp, B.E., et al. 1988. Methods Enzymol. 159, 173.
Product Information
CAS number121932-06-7
ATP CompetitiveN
FormSolid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₈₀H₁₃₀N₂₈O₂₄
Chemical formulaC₈₀H₁₃₀N₂₈O₂₄
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKA
Primary Target K<sub>i</sub> 1.7 nM against protein kinase A
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539684 0

Documentation

PKA Inhibitor 6-22 Amide - CAS 121932-06-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PKA Inhibitor 6-22 Amide - CAS 121932-06-7 - Calbiochem Certificates of Analysis

TitleLot Number
539684

References

Reference overview
Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
Kemp, B.E., et al. 1988. Methods Enzymol. 159, 173.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-September-2008 RFH
SynonymsPKI 6-22 Amide, TYADFIASGRTGRRNAI-NH₂, Protein Kinase A Inhibitor 6-22 Amide, PKA Inhibitor VIII
DescriptionA potent and competitive inhibitor of PKA (Ki = 1.7 nM).
FormSolid
FormulationSupplied as a trifluoroacetate salt.
CAS number121932-06-7
Chemical formulaC₈₀H₁₃₀N₂₈O₂₄
Peptide SequenceH-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
Purity≥97% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGlass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
Kemp, B.E., et al. 1988. Methods Enzymol. 159, 173.