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528111 PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV

Primary Target: PI 3-Kα
528111
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1188890-32-5C₁₆H₁₅N₃O₂S • 2HCl

Products

Catalogue NumberPackaging Qty/Pack
528111-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
Catalogue Number528111
Brand Family Calbiochem®
Synonyms3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV
References
ReferencesHayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.
Product Information
CAS number1188890-32-5
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₁₅N₃O₂S • 2HCl
Chemical formulaC₁₆H₁₅N₃O₂S • 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI 3-Kα
Primary Target IC<sub>50</sub>2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528111-5MG 04055977270525

Documentation

PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem Certificates of Analysis

TitleLot Number
528111

References

Reference overview
Hayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV
DescriptionA cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-Ks (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥ 3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1188890-32-5
Chemical formulaC₁₆H₁₅N₃O₂S • 2HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesHayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.