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489530 NOR-3

A cell-permeable, non-thiol, nitric oxide (NO) donor that can spontaneously release NO in a rate controlled manner (half-life (t1/2) in PBS, pH 7.4 is 30 minutes at 37°cC) generating biologically inactive by-products.

NOR-3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK 409

489530
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
163180-49-2C₈H₁₃N₃O₄
Description
Overview

This product has been discontinued.





A cell-permeable, non-thiol, nitric oxide (NO) donor that can spontaneously release NO in a rate controlled manner (half-life (t½) in PBS, pH 7.4 is 30 minutes at 37°C) generating biologically inactive by-products. Spontaneously releases NO intra- and extracellularly and activates intracellular soluble guanylate cyclase, leading to an increase in cGMP level and subsequent vascular relaxation or inhibition of platelet aggregation. Note: 1 set = 10 x 1 mg.
Catalogue Number489530
Brand Family Calbiochem®
Synonyms(±)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK 409
References
ReferencesPercival, M.D., et al. 1999. Biochemistry 38, 13574.
Kita, Y., et al. 1994. Br. J. Pharmacol. 113, 385.
Kita, Y., et al. 1994. Eur. J. Pharmacol. 257, 123.
Shibata, S., et al. 1991. J. Cardiovasc. Pharmacol. 17, 508.
Yamada, H., et al. 1991. Br. J. Pharmacol. 103, 1713.
Hino, N., et al. 1989. J. Antibiot. 42, 1578.
Product Information
CAS number163180-49-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₃N₃O₄
Chemical formulaC₈H₁₃N₃O₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetNon-thiol, nitric oxide (NO) donor
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
489530 0

Documentation

NOR-3 SDS

Title

Safety Data Sheet (SDS) 

NOR-3 Certificates of Analysis

TitleLot Number
489530

References

Reference overview
Percival, M.D., et al. 1999. Biochemistry 38, 13574.
Kita, Y., et al. 1994. Br. J. Pharmacol. 113, 385.
Kita, Y., et al. 1994. Eur. J. Pharmacol. 257, 123.
Shibata, S., et al. 1991. J. Cardiovasc. Pharmacol. 17, 508.
Yamada, H., et al. 1991. Br. J. Pharmacol. 103, 1713.
Hino, N., et al. 1989. J. Antibiot. 42, 1578.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
Synonyms(±)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK 409
DescriptionA cell-permeable nitric oxide (NO) donor that can release NO spontaneously in a rate controlled manner (t½ = 40 min) generating biologically inactive by-products. Spontaneously releases NO intra- and extracellularly and activates intracellular soluble guanylate cyclase, leading to an increase in the cGMP level and subsequent vascular relaxation or inhibition of platelet aggregation.
FormWhite solid
CAS number163180-49-2
Chemical formulaC₈H₁₃N₃O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml). Further dilute with buffer just prior to use.
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
ReferencesPercival, M.D., et al. 1999. Biochemistry 38, 13574.
Kita, Y., et al. 1994. Br. J. Pharmacol. 113, 385.
Kita, Y., et al. 1994. Eur. J. Pharmacol. 257, 123.
Shibata, S., et al. 1991. J. Cardiovasc. Pharmacol. 17, 508.
Yamada, H., et al. 1991. Br. J. Pharmacol. 103, 1713.
Hino, N., et al. 1989. J. Antibiot. 42, 1578.