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487957 NOC-18 - CAS 146724-94-9 - Calbiochem

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

NOC-18 - CAS 146724-94-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate

487957
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
146724-94-9C₄H₁₃N₅O₂

Products

Catalogue NumberPackaging Qty/Pack
487957-10MG Plastic ampoule 10 mg
Description
OverviewA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro. Half-life (t½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).
Catalogue Number487957
Brand Family Calbiochem®
SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
References
ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
Product Information
CAS number146724-94-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₄H₁₃N₅O₂
Chemical formulaC₄H₁₃N₅O₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA nitric oxide (NO) donor
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
487957-10MG 04055977200430

Documentation

NOC-18 - CAS 146724-94-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NOC-18 - CAS 146724-94-9 - Calbiochem Certificates of Analysis

TitleLot Number
487957

References

Reference overview
Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-July-2019 JSW
SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
DescriptionA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro.
FormWhite solid
CAS number146724-94-9
Chemical formulaC₄H₁₃N₅O₂
Structure formulaStructure formula
Purity≥90% by HPLC
Solubility0.1N NaOH (10 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
Toxicity Irritant
ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.