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475895 Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem

Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
475895
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
22373-78-0C₃₆H₆₁O₁₁ . Na
Description
OverviewPolyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.
Catalogue Number475895
Brand Family Calbiochem®
References
ReferencesInabayashi, M., et al. 1995. Biochemistry 34, 3455.
Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123.
Kok, J.W. 1992. J. Cell. Sci. 103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.
Product Information
CAS number22373-78-0
ATP CompetitiveN
FormOff-white to beige solid
Hill FormulaC₃₆H₆₁O₁₁ . Na
Chemical formulaC₃₆H₆₁O₁₁ . Na
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFunctions as a Na+ ionophore
Purity≥97% by Assay
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSJH2830000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475895 0

Documentation

Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem Certificates of Analysis

TitleLot Number
475895

References

Reference overview
Inabayashi, M., et al. 1995. Biochemistry 34, 3455.
Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123.
Kok, J.W. 1992. J. Cell. Sci. 103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-January-2011 JSW
DescriptionPolyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.
FormOff-white to beige solid
CAS number22373-78-0
RTECSJH2830000
Chemical formulaC₃₆H₆₁O₁₁ . Na
Structure formulaStructure formula
Purity≥97% by Assay
SolubilityChloroform, Ethanol, or Methanol
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.
Toxicity Highly Toxic
Merck USA index14, 6246
ReferencesInabayashi, M., et al. 1995. Biochemistry 34, 3455.
Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123.
Kok, J.W. 1992. J. Cell. Sci. 103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.