Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

530031 Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mitochondrial DNA Damaging Agent, mtPt

530031
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₈H₁₀₉N₂₂O₁₀Ptplus;
Description
Overview

This product has been discontinued.



A platinum-based cisplatin analogue (cis-{Pt(NH3)2}2+) conjugated to a mitochondria-penetrating peptide that localizes to mitochondria to induce mitochondrial DNA damage in ovarian cancer cells, but has minimal effect on normal cells. Shown to be effective even in cisplatin-resistant A2780CP70 cells (IC50 = 5.0 µM). Has a much lower resistance factor when compared to cisplatin (0.7 vs 8.7). Exhibits reduced toxicity compared to cisplatin. Diminishes the amplification of the mitochondrial, but not the nuclear DNA segment. Shown to cause a statistically significant reduction in the amplification of the mitochondrial but not nuclear DNA segment, and increases reactive oxygen species (ROS) product.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530031
Brand Family Calbiochem®
SynonymsMitochondrial DNA Damaging Agent, mtPt
References
ReferencesWisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.
Product Information
FormWhite powder
Hill FormulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
Chemical formulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Primary Target IC<sub>50</sub>5 µM in cisplatin-resistant A2780CP70 cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
530031 0

Documentation

Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem Certificates of Analysis

TitleLot Number
530031

References

Reference overview
Wisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2014 JSW
SynonymsMitochondrial DNA Damaging Agent, mtPt
DescriptionA platinum-based cisplatin analogue (cis-{Pt(NH3)2}2+) conjugated to a mitochondria-penetrating peptide that localizes to mitochondria to induce mitochondrial DNA damage in ovarian cancer cells, but has minimal effect on normal cells. Shown to be effective even in cisplatin-resistant A2780CP70 cells (IC50 = 5.0 µM). Has a much lower resistance factor when compared to cisplatin (0.7 vs 8.7). Exhibits reduced toxicity compared to cisplatin. Diminishes the amplification of the mitochondrial, but not the nuclear DNA segment. Shown to cause a statistically significant reduction in the amplification of the mitochondrial but not nuclear DNA segment, and increases reactive oxygen species (ROS) product.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Toxicity Standard Handling
ReferencesWisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.