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508052 Midkine Inhibitor, iMDK - CAS 881970-80-5 - Calbiochem

508052
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Overview

Key Spec Table

CAS #Empirical Formula
881970-80-5C₂₁H₁₃FN₂O₂S

Products

Catalogue NumberPackaging Qty/Pack
5.08052.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable imidazothiazolyl-chromenone compound that reduces cellular midkine/MDK protein level in H441 lung adenocarcinoma cells in a dose-dependent manner (by >90% in 48 h at 25 nM) via a yet unidentified mechanism. Shown to inhibit the viability of MDK-positive HEK293, H441, and H520 cells (by ≥60% at 500 nM in 48 h), but not MDK-negative NHLF or HEK293 (by <15% at 500 nM in 48 h), via apoptosis induction as a result of PI 3-K/AKT signaling inhibition. Intraperitoneal injection is reported to be efficacious in retarding H441 tumor expansion in mice (9 mg/kg; 3X to 5X per wk) in vivo.
Catalogue Number508052
Brand Family Calbiochem®
SynonymsMDK Expression Inhibitor, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl)-2H-chromen-2-one
References
ReferencesHao, H., et al. 2013. PLoS ONE 8, e71093.
Product Information
CAS number881970-80-5
FormOff-white solid
Hill FormulaC₂₁H₁₃FN₂O₂S
Chemical formulaC₂₁H₁₃FN₂O₂S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMidkine
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5.08052.0001 04055977242805