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654271 MetAP2 Inhibitor, A832234 - Calbiochem

The MetAP2 Inhibitor, A832234 controls the biological activity of MetAP2.

MetAP2 Inhibitor, A832234 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Methionine aminopeptidase-2 Inhibitor, 2-[({2-[(1Z)-3-(Diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic Acid, Methionyl aminopeptidase 2 Inhibitor

Primary Target: MetAP2
654271
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₂₉FN₂O₄S
Description
Overview

This product has been discontinued.



A cell-permeable anthranilic acid sulfonamide compound that acts as a potent and reversible inhibitor of methionine aminopetidase-2 (MetAP2, IC50 = 11 nM). Acts by directly targeting the active site of MetAP2 without any significant binding to human serum albumin. Also shown to inhibit cellular MetAP2 activity (EC50 = 5.3 nM) and block the proliferation of HT1080 fibrosarcoma cells (EC50 = 6 nM).
Catalogue Number654271
Brand Family Calbiochem®
SynonymsMethionine aminopeptidase-2 Inhibitor, 2-[({2-[(1Z)-3-(Diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic Acid, Methionyl aminopeptidase 2 Inhibitor
References
ReferencesSheppard, G. S., et al. 2006. J Med Chem. 49, 3832
Product Information
FormLight beige solid
Hill FormulaC₂₄H₂₉FN₂O₄S
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetMetAP2
Primary Target IC<sub>50</sub>11 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
654271 0

Documentation

MetAP2 Inhibitor, A832234 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MetAP2 Inhibitor, A832234 - Calbiochem Certificates of Analysis

TitleLot Number
654271

References

Reference overview
Sheppard, G. S., et al. 2006. J Med Chem. 49, 3832
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
SynonymsMethionine aminopeptidase-2 Inhibitor, 2-[({2-[(1Z)-3-(Diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic Acid, Methionyl aminopeptidase 2 Inhibitor
DescriptionA cell-permeable anthranilic acid sulfonamide compound that acts as a potent and reversible inhibitor of methionine aminopetidase-2 (MetAP2, IC50 = 11 nM). Acts by directly targeting the active site of MetAP2 without any significant binding to human serum albumin. Also shown to inhibit cellular MetAP2 activity (EC50 = 5.3 nM) and block the proliferation of HT1080 fibrosarcoma cells (EC50 = 6 nM).
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml; pale yellow solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSheppard, G. S., et al. 2006. J Med Chem. 49, 3832