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454861 MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I

Primary Target: Mitogen-activated protein kinase-interacting kinase 1 (MNK1)
454861
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
522629-08-9C₁₁H₉FN₆
Description
OverviewA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
Catalogue Number454861
Brand Family Calbiochem®
Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
References
ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
Worch, J., et al. 2004. Oncogene 23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
Product Information
CAS number522629-08-9
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₁H₉FN₆
Chemical formulaC₁₁H₉FN₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMitogen-activated protein kinase-interacting kinase 1 (MNK1)
Primary Target IC<sub>50</sub>2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
454861 0

Documentation

MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem Certificates of Analysis

TitleLot Number
454861

References

Reference overview
Topisirovic, I., et al. 2004. Cancer Res. 64, 8639.
Worch, J., et al. 2004. Oncogene 23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-September-2012 JSW
Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
DescriptionA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number522629-08-9
Chemical formulaC₁₁H₉FN₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (15 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic
ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
Worch, J., et al. 2004. Oncogene 23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.