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444285 MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS

Primary Target: MMP-2
444285
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
869577-53-7C₁₆H₁₇NO₅S₃
Description
Overview

This product has been discontinued.



A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and > 25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and > 25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
Catalogue Number444285
Brand Family Calbiochem®
Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
References
ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
Product Information
CAS number869577-53-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₁₇NO₅S₃
Chemical formulaC₁₆H₁₇NO₅S₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2
Primary Target K<sub>i</sub>16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively
Purity≥85% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444285 0

Documentation

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Certificates of Analysis

TitleLot Number
444285

References

Reference overview
Ikejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
DescriptionA cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and >25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number869577-53-7
Chemical formulaC₁₆H₁₇NO₅S₃
Structure formulaStructure formula
Purity≥85% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.