444937 Sigma-AldrichMEK Inhibitor I - CAS 297744-42-4 - Calbiochemv
The MEK Inhibitor I, also referenced under CAS 297744-42-4, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The MEK Inhibitor I, also referenced under CAS 297744-42-4, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 297744-42-4 | C₂₁H₁₈N₄OS |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 444937-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | A cell-permeable pyridine-containing vinylogous cyanamide compound that acts as a potent and selective inhibitor of MEK (IC50 = 12 nM) with little activity towards MKK3 and MKK4 (IC50 > 1 µM). The inhibition is noncompetitive with respect to ERK and the compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP). Exhibits superior potency, solubility, and stability compared to U0126 (Cat. No. 662005) in aqueous solutions. Shown to protect against phorbol ester-mediated ear edema in mice (ED50 of 5 mg/kg, ip.). |
| Catalogue Number | 444937 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Wityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14, 1483. |
| Product Information | |
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| CAS number | 297744-42-4 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₁H₁₈N₄OS |
| Chemical formula | C₂₁H₁₈N₄OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | MEK |
| Primary Target IC<sub>50</sub> | 12 nM against MEK |
| Purity | ≥ 95% by HPLC (sum of two isomers) |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 444937-1MG | 04055977186215 |
Documentation
MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv SDS
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MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv Certificates of Analysis
| Title | Lot Number |
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| 444937 |
References
| Reference overview |
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| Wityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14, 1483. |