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23-032 Sigma-AldrichMDM2/CK1δ Protein, active, 10 µg

Active, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active (Item # 14-520). For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

MDM2/CK1δ Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA

Key Applications: Enzyme Assays

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Overview

Key Spec Table

Key Applications	Species	Cascade Component
Enzyme Assays	Human	E3

Description
Catalogue Number	23-032
Brand Family	Upstate
Trade Name	Upstate
Description	MDM2/CK1δ Protein, active, 10 µg
Overview	N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli.
Alternate Names	Double minute 2 protein p53-binding protein Mdm2 Hdm2
Background Information	MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.

Product Information
Quality Level	MQ100

Applications
Application	Active, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active (Item # 14-520). For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Key Applications	Enzyme Assays

Biological Information
Specific Activity	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Cascade Component	E3
Entrez Gene Number	AF527840
Purification Method	Purified using glutathione sepharose followed by gel filtration.

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Packaging Information
Material Size	10 µg

Global Trade Item Number
Catalogue Number	GTIN
23-032	04053252294778

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