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437625 Lipopolysaccharide, E. coli O55: B5 - Calbiochem

Lipopolysaccharide, E. coli O55: B5, stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
437625
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.



Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
Catalogue Number437625
Brand Family Calbiochem®
References
ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
Product Information
ATP CompetitiveN
FormLyophilized
ReversibleN
Quality LevelMQ100
Applications
ApplicationLipopolysaccharide, E. coli O55: B5, stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
Biological Information
Primary TargetStimulates the activity of inducible nitric oxide synthase
Physicochemical Information
Cell permeableN
Contaminantsprotein: ≤2.0%; nucleic acid: ≤1.3%
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSJZ2650000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
437625 0

Documentation

Lipopolysaccharide, E. coli O55: B5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Lipopolysaccharide, E. coli O55: B5 - Calbiochem Certificates of Analysis

TitleLot Number
437625

References

Reference overview
Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
DescriptionEndotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
FormLyophilized
RTECSJZ2650000
Contaminantsprotein: ≤2.0%; nucleic acid: ≤1.3%
SolubilityH₂O
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Toxicity Harmful
ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.