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14-619M LMPTP-A Protein, 250 µg

GST-tagged, recombinant, full length, human LMPTP-A, for use in Phosphatase Assays.

14-619M
250 µg  Also available in 10 μg size (cat#14-619) and in bulk (cat#14-619-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-619M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionLMPTP-A Protein, 250 µg
OverviewGST-tagged, recombinant, full length, human LMPTP-A
References
Product Information
Quality LevelMQ300
Applications
ApplicationGST-tagged, recombinant, full length, human LMPTP-A, for use in Phosphatase Assays.
Key Applications
  • Phosphatase Assay
Biological Information
SourceExpressed in E. coli
Entrez Gene Number
Entrez Gene SummaryThe product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.
Gene Symbol
  • ACP1
  • HAAP
  • LMW-PTP
  • LMW-PTPase
  • MGC3499
  • MGC111030
Protein TargetLMPTP-A
Purification MethodGlutathione agarose affinity chromatography
Target Sub-FamilyTyr phosphatase
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P24666 # Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
SIZE: 158 amino acids; 18042 Da
SUBUNIT: Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: T-lymphocytes express only isoform 2.
SIMILARITY: SwissProt: P24666 ## Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Molecular Weight44.5kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by dephosphorylation of DiFMUP
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-619) and in bulk (cat#14-619-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-619M 04053252924361

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-619 LMPTP-A Protein, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Phosphatases
Life Science Research > Proteins and Enzymes > Purified Phosphatases