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108396 L-Tryptophan

EMPROVE® EXPERT Ph Eur,BP,JP,USP

L-Tryptophan MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trp

CAS #: 73-22-3 EC Number: 200-795-6 Molar Mass: 204.23 g/mol Hill Formula: C₁₁H₁₂N₂O₂ Grade: Ph Eur,BP,JP,USP
108396
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
73-22-3200-795-6C₁₁H₁₂N₂O₂204.23 g/molPh Eur,BP,JP,USP

Products

Catalogue NumberPackaging Qty/Pack
1083961000 Plastic bottle 1 kg
1083969010 Plastic drum 10 kg
Description
Catalogue Number108396
SynonymsTrp
References
Product Information
CAS number73-22-3
EC number200-795-6
GradePh Eur,BP,JP,USP
Hill FormulaC₁₁H₁₂N₂O₂
Molar Mass204.23 g/mol
HS Code2933 99 99
Structure formula ImageStructure formula Image
Quality LevelMQ500
Applications
Biological Information
Physicochemical Information
Melting Point290 °C (decomposition)
pH value5.5 - 7 (1 g/l, H₂O, 25 °C)
Bulk density400 kg/m3
Solubility10 g/l
Dimensions
Materials Information
Toxicological Information
LD 50 oralLD50 Rat 16000 mg/kg
Safety Information according to GHS
RTECSYN6130000
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Disposal3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +30°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Assay (perchloric acid titration, calculated on dried substance)98.5 - 101.0 %
Identity (IR-spectrum)passes test
Identity (specific rotation)passes test
Appearancewhite to almost white, crystalline or amorphous powder
Appearance of solution (10 g/l, Hydrochloric acid 1 mol/l)clear and not more intense in color than reference solution BY₆
Appearance of solution (20 g/l, hydrochloric acid 2 mol/l)clear
pH (10 g/l, CO₂-free water)5.5 - 6.4
Spec. rotation (α 20/D, 10 g/l, water, calc. on dried substance)-30.0 to -33.0
Spec. rotation (α 25/D, 10 g/l, water, calc. on dried substance)-29.4 to -32.8
Spec. rotation (α 20/D, 10 g/l, water, previously dried substance)-30.0 to -33.0
Chloride (Cl)≤ 200 ppm
Sulfate (SO₄)≤ 200 ppm
Heavy metals (as Pb)≤ 20 ppm
Fe (Iron)≤ 20 ppm
As (Arsenic)≤ 2 ppm
Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
Ninhydrin-positive substances (LC) (total impurities)≤ 0.5 %
Related substances (HPLC)passes test
Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to Ph Eur)≤ 10 ppm
Sum of impurities with RT < tryptophan-peak (acc. to Ph Eur)≤ 100 ppm
Sum of impurities with RT > tryptophan-peak and up to1,8 times the RT ofacetyltryptophan (acc. to Ph Eur)≤ 300 ppm
Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to USP)≤ 10 ppm
Sum of impurities with RT < tryptophan-peak (acc. to USP)≤ 100 ppm
Sum of impurities with RT > tryptophan-peak, without tryptophan-peak andpeak of „Related Compound B“ (N-acetyltryptophan) (acc. to USP)≤ 300 ppm
Related substances (TLC)passes test
Residual solvents (ICH (Q3C))excluded by manufacturing process
Sulfated ash (600 °C)≤ 0.1 %
Loss on drying (105 °C; 3 h)≤ 0.30 %
Bacterial endotoxins≤ 10 I.U./g
Microbiological test (total aerobic microbial count (TAMC))≤ 100 CFU/g
Microbiological test (total yeast and mould count (TYMC))≤ 100 CFU/g
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., BP, JP, USP.
Global Trade Item Number
Catalogue Number GTIN
1083961000 04022536104003
1083969010 04022536732701

Documentation

Material Qualification Dossier

TitleVersion
9.0

Quality Management Dossier (Open Access)

Title

Operational Excellence Dossier

Title

L-Tryptophan SDS

Title

Safety Data Sheet (SDS) 

L-Tryptophan Certificates of Analysis

Product Number PackagingSpecificationLot Number
1083961000 Plastic bottlePDF Specification Document
1083969010 Plastic drumPDF Specification Document

Certificates

Title