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420143 JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem

The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide

420143
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1164153-22-3C₂₇H₂₇N₅O₅

Products

Catalogue NumberPackaging Qty/Pack
420143-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
Catalogue Number420143
Brand Family Calbiochem®
Synonyms3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
References
ReferencesKamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.
Product Information
CAS number1164153-22-3
FormOff-white solid
Hill FormulaC₂₇H₂₇N₅O₅
Chemical formulaC₂₇H₂₇N₅O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420143-5MG 04055977211092

Documentation

JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem Certificates of Analysis

TitleLot Number
420143

References

Reference overview
Kamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
DescriptionA cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1164153-22-3
Chemical formulaC₂₇H₂₇N₅O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.