504924 Sigma-AldrichIndomethacin, 2ʹ-Trifluoromethyl - Calbiochem
Recommended Products
Overview
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Key Spec Table
| Empirical Formula |
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| C₁₉H₁₃ClF₃NO₄ |
| Description | |
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| Overview | This product has been discontinued. A cell-permeable, bioavailable 2′-trifluoromethyl analog of Indomethacin (Cat. No. 405268) that acts as a highly potent, time-dependent inhibitor of cyclooxygenase -2 (COX-2; IC50 = 267 and 388 nM for mouse and human COX-2, respectively) and its several mutant forms. Does not affect COX-1 activity even at high concentrations (IC50 >100 µM). Interacts with human COX-2 with much greater affinity than indomethacin (KI = 1.5 vs 13 µM) and blocks COX-2 dependent arachidonic acid oxygenation (IC50 = 150 nM in 1483 human head and neck squamous cell carcinoma cells). Further, minimizes swelling in carrageenan-induced rat paw edema model (EC50 = 1.7 mg/kg, p.o.) with no gastrointestinal bleeding at higher doses (10 mg/kg). |
| Catalogue Number | 504924 |
| Brand Family | Calbiochem® |
| Synonyms | Indomethacin, 2ʹ-Trifluoromethyl; Indomethacin, 2-CF₃, CF₃-Indomethacin; CF₃-INDO |
| References | |
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| References | Blobaum, A.L., et al. 2013. ACS Med. Chem. Lett. 4, 486. |
| Product Information | |
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| Form | White powder |
| Hill Formula | C₁₉H₁₃ClF₃NO₄ |
| Chemical formula | C₁₉H₁₃ClF₃NO₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | COX-2 |
| Primary Target IC<sub>50</sub> | 267 and 388 nM for mouse and human COX-2, respectively |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 504924 | 0 |
Documentation
Indomethacin, 2ʹ-Trifluoromethyl - Calbiochem SDS
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References
| Reference overview |
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| Blobaum, A.L., et al. 2013. ACS Med. Chem. Lett. 4, 486. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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