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553212 InSolution™ Rapamycin in EtOH

The InSolution™ Rapamycin, also referenced under CAS 53123-88-9, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Rapamycin in EtOH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sirolimus, mTOR Inhibitor I

553212
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₁H₇₉NO₁₃
Description
Catalogue Number553212
Brand Family Calbiochem®
SynonymsSirolimus, mTOR Inhibitor I
References
ReferencesPowell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
Braun, W., et al. 1995. FASEB J. 9, 63.
Nielsen, F.C., et al. 1995. Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
Kuo, J., et al. 1992. Nature 358, 70.
Price, D.J., et al. 1992. Science 257, 973.
Heitman, J., et al. 1991. Science 253, 905.
Kay, J.E., et al. 1991. Immunology 72, 544.
Schreiber, S.L. 1991. Science 251, 283.
Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
Product Information
FormLiquid
FormulationA 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553210) in EtOH.
Hill FormulaC₅₁H₇₉NO₁₃
Chemical formulaC₅₁H₇₉NO₁₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 11

Highly flammable.
S PhraseS: 16-7

Keep away from sources of ignition - No Smoking.
Keep container tightly closed.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
553212 0

Documentation

InSolution™ Rapamycin in EtOH SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Rapamycin in EtOH Certificates of Analysis

TitleLot Number
553212

References

Reference overview
Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
Braun, W., et al. 1995. FASEB J. 9, 63.
Nielsen, F.C., et al. 1995. Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
Kuo, J., et al. 1992. Nature 358, 70.
Price, D.J., et al. 1992. Science 257, 973.
Heitman, J., et al. 1991. Science 253, 905.
Kay, J.E., et al. 1991. Immunology 72, 544.
Schreiber, S.L. 1991. Science 251, 283.
Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-September-2008 JSW
SynonymsSirolimus, mTOR Inhibitor I
DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 0.05 nM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
FormLiquid
FormulationA 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553210) in EtOH.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₅₁H₇₉NO₁₃
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Flammable
Merck USA index14, 8114
ReferencesPowell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
Braun, W., et al. 1995. FASEB J. 9, 63.
Nielsen, F.C., et al. 1995. Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
Kuo, J., et al. 1992. Nature 358, 70.
Price, D.J., et al. 1992. Science 257, 973.
Heitman, J., et al. 1991. Science 253, 905.
Kay, J.E., et al. 1991. Immunology 72, 544.
Schreiber, S.L. 1991. Science 251, 283.
Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
Dumont, F.J., et al. 1990. J. Immunol. 144, 251.