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508739 InSolution™ Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

A 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione

508739
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
66-81-9C₁₅H₂₃NO₄
Description
Catalogue Number508739
Brand Family Calbiochem®
Synonyms4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione
References
ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Product Information
CAS number66-81-9
FormLiquid
FormulationA 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity (Cat. No. 239764) in DMSO.
Hill FormulaC₁₅H₂₃NO₄
Chemical formulaC₁₅H₂₃NO₄
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary Targettranslocase enzyme
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 28-51/53-61

Very toxic if swallowed.
Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
May cause harm to the unborn child.
S PhraseS: 45-53-61

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Avoid release to the environment. Refer to special instructions/safety data sheet.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
508739 0

Documentation

InSolution™ Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
Synonyms4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione
DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
FormLiquid
FormulationA 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity (Cat. No. 239764) in DMSO.
CAS number66-81-9
Chemical formulaC₁₅H₂₃NO₄
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
Avoid freeze/thaw
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.