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407248 IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401

Primary Target: IGF-1R
407248
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
196868-63-0C₁₈H₁₆ClN₃O₂
Description
OverviewA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
Catalogue Number407248
Brand Family Calbiochem®
SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
References
ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.
Product Information
CAS number196868-63-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₈H₁₆ClN₃O₂
Chemical formulaC₁₈H₁₆ClN₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIGF-1R
Primary Target IC<sub>50</sub>12 µM in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay; 8 and 15 µM in reducing IGF-1R-dependent tumor cell growth both in vitro for MCF-7 and MCNeuA, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407248 0

Documentation

IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem Certificates of Analysis

TitleLot Number
407248

References

Reference overview
Gable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
DescriptionA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week per i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number196868-63-0
Chemical formulaC₁₈H₁₆ClN₃O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (3 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.