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400046 Hydroxyurea - CAS 127-07-1 - Calbiochem

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Hydroxyurea - CAS 127-07-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

Primary Target: Inhibiting ribonucleotide reductase
400046
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
127-07-1CH₄N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
400046-5GM Plastic ampoule 5 gm
Description
OverviewAnti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Catalogue Number400046
Brand Family Calbiochem®
SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
References
ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett. 88, 101.
Product Information
CAS number127-07-1
ATP CompetitiveN
FormWhite solid
Hill FormulaCH₄N₂O₂
Chemical formulaCH₄N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibiting ribonucleotide reductase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYT4900000
Safety Information
R PhraseR: 46-61

May cause heritable genetic damage.
May cause harm to the unborn child.
S PhraseS: 45-53

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
400046-5GM 04055977212129

Documentation

Hydroxyurea - CAS 127-07-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Hydroxyurea - CAS 127-07-1 - Calbiochem Certificates of Analysis

TitleLot Number
400046

References

Reference overview
Leyden, D., et al. 2000. Anticancer Res. 20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett. 88, 101.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-November-2018 JSW
SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
DescriptionAntineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
FormWhite solid
CAS number127-07-1
RTECSYT4900000
Chemical formulaCH₄N₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 4848
ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett. 88, 101.