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373401 Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem

373401
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
500579-04-4C₂₇H₃₅N₅
Description
OverviewA cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 = ~ 5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. Also available as a 25 mM solution in DMSO (Cat. No. 373403).
Catalogue Number373401
Brand Family Calbiochem®
Synonyms2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline, NSC 136476
References
ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
Product Information
CAS number500579-04-4
FormOff-white solid
Hill FormulaC₂₇H₃₅N₅
Chemical formulaC₂₇H₃₅N₅
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
373401 0

Documentation

Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem Certificates of Analysis

TitleLot Number
373401

References

Reference overview
Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline, NSC 136476
DescriptionA cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number500579-04-4
Chemical formulaC₂₇H₃₅N₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.