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375670 Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem

A potent and cell-permeable protein tyrosine kinase inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: P60v-src
375670
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
70563-58-5C₃₀H₄₂N₂O₉
Description
OverviewA potent and cell-permeable protein tyrosine kinase inhibitor. Inhibits p60v-src (IC50 = 12 µM) and PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Reported to inhibit c-Src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane. Also shown to inhibit anti-CD3 monoclonal antibody-induced apoptosis of thymocytes.
Catalogue Number375670
Brand Family Calbiochem®
References
ReferencesFan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
Migita, K., et al. 1994. J. Immunol. 153, 3457.
Okabe, M., et al. 1994. Leuk. Res. 18, 867.
Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
Uehara, Y., et al. 1988. Virology 164, 294.
Omura, S., et al. 1979. J. Antibiotics 32, 255.
Product Information
CAS number70563-58-5
ATP CompetitiveN
FormYellow solid
Hill FormulaC₃₀H₄₂N₂O₉
Chemical formulaC₃₀H₄₂N₂O₉
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP60v-src
Primary Target IC<sub>50</sub>12 µM against P60v-src
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLX8930000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
375670 0

Documentation

Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem Certificates of Analysis

TitleLot Number
375670

References

Reference overview
Fan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
Migita, K., et al. 1994. J. Immunol. 153, 3457.
Okabe, M., et al. 1994. Leuk. Res. 18, 867.
Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
Uehara, Y., et al. 1988. Virology 164, 294.
Omura, S., et al. 1979. J. Antibiotics 32, 255.

Citations

Title
  • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
  • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-July-2008 RFH
    DescriptionA cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 µM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.
    FormYellow solid
    CAS number70563-58-5
    RTECSLX8930000
    Chemical formulaC₃₀H₄₂N₂O₉
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (1 mg/ml). Further dilute with H₂O or aqueous buffers just prior to use.
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
    Toxicity Carcinogenic / Teratogenic
    ReferencesFan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
    Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
    Migita, K., et al. 1994. J. Immunol. 153, 3457.
    Okabe, M., et al. 1994. Leuk. Res. 18, 867.
    Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
    Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
    Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
    Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
    Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
    Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
    Uehara, Y., et al. 1988. Virology 164, 294.
    Omura, S., et al. 1979. J. Antibiotics 32, 255.
    Citation
  • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
  • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
    		•