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374000 Helenalin, A. chamissonis ssp. foliosa

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
374000
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
374000-500UG Glass bottle 500 μg
Description
OverviewA cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.
Catalogue Number374000
Brand Family Calbiochem®
References
ReferencesBoulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
Lyss, G., et al. 1997. Biol. Chem. 378, 951.
Product Information
CAS number6754-13-8
FormWhite to off-white solid
Hill FormulaC₁₅H₁₈O₄
Chemical formulaC₁₅H₁₈O₄
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBD9630000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Toxic
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
374000-500UG 04055977191158

Documentation

Helenalin, A. chamissonis ssp. foliosa SDS

Title

Safety Data Sheet (SDS) 

Helenalin, A. chamissonis ssp. foliosa Certificates of Analysis

TitleLot Number
374000

References

Reference overview
Boulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
Lyss, G., et al. 1997. Biol. Chem. 378, 951.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-April-2011 RFH
DescriptionA cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number6754-13-8
RTECSBD9630000
Chemical formulaC₁₅H₁₈O₄
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
Merck USA index14, 4626
ReferencesBoulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
Lyss, G., et al. 1997. Biol. Chem. 378, 951.