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500671 HDAC Inhibitor XVII - Calbiochem

HDAC Inhibitor XVII - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII

Primary Target: HDAC8 selective
500671
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₁₉NO₃
Description
Overview

This product has been discontinued.



A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27 nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0 µM), HDAC2/4/6/10/11 (IC50 >20 µM), or total HDAC activity in HeLa nuclear extract (IC50 >10 µM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8 µM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40 µM).
Catalogue Number500671
Brand Family Calbiochem®
Synonyms(E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII
References
ReferencesHuang, W. J., et al. 2012. ChemMedChem. 7, 1815.
Product Information
FormLight beige powder
Hill FormulaC₂₂H₁₉NO₃
Chemical formulaC₂₂H₁₉NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHDAC8 selective
Primary Target IC<sub>50</sub>27 nM
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
500671 0

Documentation

HDAC Inhibitor XVII - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Huang, W. J., et al. 2012. ChemMedChem. 7, 1815.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
Synonyms(E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII
DescriptionA cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27 nM), displaying much reduced potency against HDAC1/3 (IC50 = 3.0 µM) and little or no activity toward HDAC2/4/6/10/11 (IC50 >20 µM) or total HDAC activity in HeLa nuclear extract (IC50 >10 µM). Reported to exhibit antiproliferative activity toward human lung cancer cells CL1-5, H1299, and A549 (IC50 = 7.0, 7.2, and 7.9 µM, respectively), while being much less toxic to low HDAC8-expressing CL1-1 (IC50 >10 µM) or normal human lung IMR-90 (73% inhibition at 40 µM) cells.
FormLight beige powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₁₉NO₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHuang, W. J., et al. 2012. ChemMedChem. 7, 1815.