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356790 Glyphosine - CAS 2439-99-8 - Calbiochem

Glyphosine - CAS 2439-99-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cp41845, Polaris, N,N-bis(Phosphonomethyl)glycine, 2-(bis(Phosphonomethyl)amino)acetic acid

356790
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2439-99-8C₄H₁₁NO₈P₂
Description
Overview

This product has been discontinued.



A glycine-phosphonic acid compound, negatively charged at neutral pH, with immunomodulatory and anti-diabetic properties. Shown to enhance CD4+ T cell response to B-chain of insulin (amino acids 9-23) even at 10 nM levels (EC50 = 70.6 nM). Occupies a pocket 9 of I-Ag7 (the class II molecules of the diabetes-prone NOD mice) and alters TCR/peptide-MHC affinity. Stimulates IL-10 secretion in splenocyes in non-obese diabetic (NOD) mice. Daily administration of glyphosine is shown to delay the onset of diabetes in NOD mice. Acts as a competitive inhibitor of phoshoenolpyruvate carboxylase in plants.
Catalogue Number356790
Brand Family Calbiochem®
SynonymsCp41845, Polaris, N,N-bis(Phosphonomethyl)glycine, 2-(bis(Phosphonomethyl)amino)acetic acid
References
ReferencesMichels, A.W., et al. 2011. J. Immunol. 187, 5921.
Stadinski, B.D., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 10978.
Podesta, F.E., et al. 1987. Plant Cell Physiol. 28, 375.
Product Information
CAS number2439-99-8
FormWhite solid
Hill FormulaC₄H₁₁NO₈P₂
Chemical formulaC₄H₁₁NO₈P₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 41

Risk of serious damage to eyes.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
356790 0

Documentation

Glyphosine - CAS 2439-99-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Glyphosine - CAS 2439-99-8 - Calbiochem Certificates of Analysis

TitleLot Number
356790

References

Reference overview
Michels, A.W., et al. 2011. J. Immunol. 187, 5921.
Stadinski, B.D., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 10978.
Podesta, F.E., et al. 1987. Plant Cell Physiol. 28, 375.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-June-2012 JSW
SynonymsCp41845, Polaris, N,N-bis(Phosphonomethyl)glycine, 2-(bis(Phosphonomethyl)amino)acetic acid
DescriptionA plant growth regulator that also enhances anti-B:9-23 (aa 9 to 23 of insulin B chain) TCR-dependent T cell activation (EC50 = 70.6 nM; ECmax = 500 nM) by modulating murine class II MHC I-Ag7-mediated B:9-23 presentation on APCs, without affecting the activation of anti-chromogranin T cells by chromogranin- I-Ag7 complex. Reported to augment B:9-23 in stimulating IL-10 production from splenocytes of diabetic NOD mice and PBMCs of type 1 diabetic individuals with HLA-DQ8, and effectively prevent the onset of diabetes in NOD mice (80 mg/kg via daily i.p.). Computer structural docking analysis indicates pocket 9 of the I-Ag7 binding groove as the glyphosine targeting site.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2439-99-8
Chemical formulaC₄H₁₁NO₈P₂
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityH₂O (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Corrosive
ReferencesMichels, A.W., et al. 2011. J. Immunol. 187, 5921.
Stadinski, B.D., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 10978.
Podesta, F.E., et al. 1987. Plant Cell Physiol. 28, 375.