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370700 GW9662 - CAS 22978-25-2 - Calbiochem

GW9662 - CAS 22978-25-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Chloro-5-nitro-N-phenylbenzamide

Primary Target: PPARγ
370700
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
22978-25-2C₁₃H₉ClN₂O₃
Description
Overview

This product has been discontinued.



A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-α (LXRα), retinoic acid receptor (RAR), retinoid X receptor-α (RXRα) and thyroid receptors α and β (TRα and TRβ).
Catalogue Number370700
Brand Family Calbiochem®
Synonyms2-Chloro-5-nitro-N-phenylbenzamide
References
ReferencesLeesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
Huang, J.T., et al. 1999. Nature 400, 378.
Product Information
CAS number22978-25-2
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₁₃H₉ClN₂O₃
Chemical formulaC₁₃H₉ClN₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPPARγ
Primary Target IC<sub>50</sub>3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
370700 0

Documentation

GW9662 - CAS 22978-25-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GW9662 - CAS 22978-25-2 - Calbiochem Certificates of Analysis

TitleLot Number
370700

References

Reference overview
Leesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
Huang, J.T., et al. 1999. Nature 400, 378.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2016 JSW
Synonyms2-Chloro-5-nitro-N-phenylbenzamide
DescriptionA cell-permeable, selective, and irreversible PPAPγ antagonist (IC50 = 3.3 nM, 32 nM, and 2.0 µM for PPARγ, PPARα, and PPARδ, respectively) that is reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor α (LXRα), retinoic acid receptor (RAR), retinoid X receptor α (RXRα), or thyroid receptors α and β (TRα and TRβ).
FormCrystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number22978-25-2
Chemical formulaC₁₃H₉ClN₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml) or Methanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLeesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
Huang, J.T., et al. 1999. Nature 400, 378.