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361569 GSK-3beta Inhibitor XXVI - Calbiochem

GSK-3beta Inhibitor XXVI - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
361569
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₁H₁₈N₄O
Description
Overview

This product has been discontinued.



A cell-permeable, pyrazolone GSK-3β inhibitor (IC50 = 34 nM, in an enzymatic assay) that is highly selective among a panel of 40 kinases that have been profiled with more than 50 fold selectivity. It exhibits no off-target activity against a panel of 44 human and rodent CNS receptors, channels, and transporters except for some modest activity toward 5HT1a. It demonstrates neuroprotective activity of neurons in an oxidative stress model induced by homocysteic acid (HCA) from 1–20 µM, without observable cytotoxicity, and is superior to SB-216763 Cat. No. 361566) at 5 µM in cell micrographs. In addition, it is shown to attenuate locomotor activity in an chlordiazepoxide/amphetamine-induced hyperactivity mice model in vivo at 150 mg/kg.
Catalogue Number361569
Brand Family Calbiochem®
References
ReferencesChen, W., et al. 2011. ChemMedChem 6, 1587.
Product Information
FormWhite solid
Hill FormulaC₂₁H₁₈N₄O
Chemical formulaC₂₁H₁₈N₄O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361569 0

Documentation

GSK-3beta Inhibitor XXVI - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3beta Inhibitor XXVI - Calbiochem Certificates of Analysis

TitleLot Number
361569

References

Reference overview
Chen, W., et al. 2011. ChemMedChem 6, 1587.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2012 JSW
DescriptionA cell-permeable, pyrazolone GSK-3β inhibitor (IC50 = 34 nM, in an enzymatic assay) that is highly selective among a panel of 40 kinases that have been profiled with more than 50 fold selectivity. It exhibits no off-target activity against a panel of 44 human and rodent CNS receptors, channels, and transporters except for some modest activity toward 5HT1a. It demonstrates neuroprotective activity of neurons in an oxidative stress model induced by homocysteic acid (HCA) from 1–20 µM, without observable cytotoxicity, and is superior to SB-216763 Cat. No. 361566) at 5 µM in cell micrographs. In addition, it is shown to attenuate locomotor activity in an chlordiazepoxide/amphetamine-induced hyperactivity mice model in vivo at 150 mg/kg.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₁₈N₄O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml; light yellow solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, W., et al. 2011. ChemMedChem 6, 1587.